{
  "id": 8076668,
  "title": "Benchmarking of bulk transcriptomic harmonization tools in a multi-platform B-cell lymphoma cohort identifies feature-specific quantile normalization and surrogate variable analysis as top-performing methods",
  "url": "https://urgent.news/2026/09/17/benchmarking-of-bulk-transcriptomic-harmonization-tools-in-a-multi",
  "topic": "science",
  "section": "Science",
  "published": "2026-09-17T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.09.15.751825v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "Cross-platform harmonization of bulk transcriptomic datasets remains a fundamental challenge for developing cancer biomarkers because of persistent unresolved batch effects. Most harmonization tools are benchmarked on datasets with large inter-group biological differences (for example TCGA tumor types), whereas actionable biomarker mining requires preserving subtle transcriptional distinctions…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}