{
  "id": 8030409,
  "title": "CRISPR/Cas9 Optimization Using Electronic Genome Mapping: Potential Role for Studying Human Genetic Disease",
  "url": "https://urgent.news/2026/09/17/crispr-cas9-optimization-using-electronic-genome-mapping-potential",
  "topic": "science",
  "section": "Science",
  "published": "2026-09-17T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.09.14.751601v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "CRISPR Cas9's ability to bind targeted and non-targeted sites and its functional interactions with other proteins and domains have been studied using many technologies. These studies are often limited by using oligos as substrates or by a reliance on predicted binding sites. We show how electronic genome mapping (EGM) with its ability to detect single-molecule DNA nicks can determine how gRNA…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}