{
  "id": 8007415,
  "title": "Gene editing using large insertions",
  "url": "https://urgent.news/2026/09/17/gene-editing-using-large-insertions",
  "topic": "science",
  "section": "Science",
  "published": "2026-09-17T00:00:00.000Z",
  "source": {
    "name": "Nature Biotechnology",
    "slug": "nature-biotechnology",
    "url": "https://www.nature.com/articles/s41587-026-03319-6"
  },
  "original_language": "en",
  "account": null,
  "summary": "Nature Biotechnology, Published online: 17 September 2026; doi:10.1038/s41587-026-03319-6 While technologies for smaller gene edits, such as base editing, have already entered clinical trials, larger gene cargoes face different challenges, including low editing efficiencies, delivery vehicle size constraints, and possible immunogenicity. Programmable genome engineering systems using recombinases;…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}