{
  "id": 8007066,
  "title": "H3-K27M mutation alters the dynamics of human hematopoietic stem cells and delays erythroid differentiation",
  "url": "https://urgent.news/2026/09/17/h3-k27m-mutation-alters-the-dynamics-of-human-hematopoietic-stem",
  "topic": "science",
  "section": "Science",
  "published": "2026-09-17T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.09.14.751581v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "Acute myeloid leukemia (AML) is an aggressive blood cancer driven by genetic and epigenetic alterations that disrupt normal hematopoiesis. Among these, the histone H3-K27M mutation, originally identified in pediatric high-grade gliomas, reshapes gene repression programs by reducing global H3-K27 trimethylation. Although rare, H3-K27M mutations have been detected in preleukemic hematopoietic stem…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}