{
  "id": 7840030,
  "title": "ERBB2 establishes the timing of progesterone priming required for uterine receptivity",
  "url": "https://urgent.news/2026/09/16/erbb2-establishes-the-timing-of-progesterone-priming-required-for",
  "topic": "science",
  "section": "Science",
  "published": "2026-09-16T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.09.14.751518v1?rss=1"
  },
  "original_language": "en",
  "account": "Progesterone is crucial for creating a receptive uterus and maintaining early pregnancy; however, the precise timing of this progesterone responsiveness remains unclear. This study reveals that the protein ERBB2 controls the timing of progesterone response needed for uterine receptivity. In endometrial samples from women experiencing recurrent miscarriages, ERBB2 levels are significantly reduced in the stromal tissue, coinciding with a decrease in stromal progesterone receptor (PGR). Deletion of the Erbb2 gene in mice causes a delay in the rise of stromal PGR at the beginning of the receptive phase, delaying implantation and impairing decidualization, even when progesterone and estrogen levels are normal. Only the stromal tissue is affected by the deletion, leaving the epithelial tissue unaffected. Administering high doses of progesterone does not restore the affected phenotype; instead, advancing progesterone priming by 24 hours successfully reinstates stromal PGR, HAND2, Bmp2, and ensures the timely implantation. The findings suggest that ERBB2 plays a pivotal role in setting the threshold for PGR induction, thereby synchronizing the maternal-fetal interface and protecting pregnancy.",
  "summary": "Progesterone is essential for establishing uterine receptivity and sustaining early pregnancy. However, how the uterus acquires the competence to respond to progesterone at the appropriate time remains poorly understood. Here we show that ERBB2 governs the timing of progesterone responsiveness required for uterine receptivity. In endometrial samples from women with recurrent spontaneous abortion…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}