{
  "id": 7840028,
  "title": "Genome-wide association study and genetic differentiation analysis reveal the genetic basis of Vibrio harveyi resistance in blackspotted croaker (Protonibea diacanthus)",
  "url": "https://urgent.news/2026/09/16/genome-wide-association-study-and-genetic-differentiation-analysis",
  "topic": "science",
  "section": "Science",
  "published": "2026-09-16T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.09.10.750604v1?rss=1"
  },
  "original_language": "en",
  "account": "Vibrio harveyi, the primary cause of vibriosis, has resulted in significant economic losses for blackspotted croaker (Protonibea diacanthus) aquaculture. The genetic factors contributing to resistance against this pathogen have not been thoroughly explored until now. To address this knowledge gap, researchers have performed the first comprehensive genome-wide association study (GWAS) and genetic differentiation analysis (F_ST) to uncover the genetic basis of Vibrio harveyi resistance in blackspotted croaker.\n\nIn the study, 450 juvenile blackspotted croaker were subjected to infection, and 300 individuals (150 resistant and 150 susceptible) were chosen for whole-genome resequencing. The genetic control of survival time (ST) and survival status (SS) was quantified through genomic heritability estimation. The results revealed moderate genetic control, with h^2 values of 0.374+/-0.29 for ST and 0.237+/-0.185 for SS.\n\nOne of the most striking findings of the study was an exceptionally high genetic correlation (r_g = 0.999) between ST and SS. This suggests that the resistance traits are closely intertwined with the survival outcomes of the blackspotted croaker. Furthermore, it was found that resistance traits were genetically independent of growth performance (r_g), indicating that the genetic factors influencing resistance are distinct from those affecting growth rates.",
  "summary": "Vibrio harveyi is a primary causative agent of vibriosis, leading to catastrophic economic losses in the blackspotted croaker (Protonibea diacanthus) aquaculture. However, the genetic architecture underlying its resistance remains poorly understood. In this study, we conducted the first integrated genome-wide association study (GWAS) and genetic differentiation analysis (F_ST) to investigate the…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}