{
  "id": 7840024,
  "title": "Atlas of Proteomic Technologies: an evidence-based framework for selecting and combining commercial proteomics platforms",
  "url": "https://urgent.news/2026/09/16/atlas-of-proteomic-technologies-an-evidence-based-framework-for",
  "topic": "science",
  "section": "Science",
  "published": "2026-09-16T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.09.10.750723v1?rss=1"
  },
  "original_language": "en",
  "account": "The Atlas of Proteomic Technologies (APT) is a groundbreaking resource designed to help researchers navigate the complex landscape of high-throughput proteomics technologies. Proteomics, the study of proteins and their functions, now encompasses a multitude of technologies that vary in their biological scope, precision, specificity, sensitivity, cost, and quantification methods. Despite the abundance of options, researchers currently lack a systematic framework to select or combine these platforms effectively.\n\nTo address this gap, APT was developed as a curated repository that rigorously evaluates six major commercial proteomics platforms across ten analytical dimensions, including biological breadth, precision, specificity, sensitivity, cost, and quantification methods. This evaluation process incorporates published head-to-head evidence, expert assessment, and iterative peer review to ensure a high level of credibility and reliability.\n\nAPT houses two innovative decision-making tools to assist researchers in making informed choices. The Help Me Choose tool enables users to map their study's primary objectives, scale, sample matrix, and technical constraints to a calibrated, weight-adjustable ranking of platforms. This tool streamlines the process of selecting a single platform tailored to specific research needs.\n\nIn addition to the Help Me Choose tool, APT features the Help Me Combine tool, which ranks pairs of complementary platforms based on their net-new protein coverage and user-specified technical priorities. This tool is particularly valuable for researchers seeking to maximize the breadth of their proteomic analyses by combining the strengths of multiple platforms.\n\nBoth decision-making tools within APT have undergone rigorous testing across all possible combinations of platforms, ensuring that their recommendations are balanced and merit-based. This rigorous testing process instills confidence in the reliability of the tools' outputs.\n\nAPT is openly accessible online at https://aptatlas.org. The website provides researchers with downloadable tool specifications, pre-seeded analysis scripts, and comprehensive protein coverage lists. This level of transparency and accessibility ensures that every score and recommendation within APT can be inspected and reproduced, promoting trust and reproducibility in proteomic research.\n\nBy offering a structured and evidence-based approach to selecting and combining proteomics platforms, APT empowers researchers to optimize their experimental designs, maximize data quality, and drive advancements in the field of proteomics.",
  "summary": "High-throughput proteomics now spans several technologies that differ in biological breadth, precision, specificity, sensitivity, cost, and method(s) of quantification; however, investigators currently lack an evidence-based framework to select or combine platforms. Here, we present the Atlas of Proteomic Technologies (APT) - a curated resource that evaluates six commercial platforms across ten…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}