{
  "id": 7839976,
  "title": "Transthyretin can denature by an alternative pathway",
  "url": "https://urgent.news/2026/09/08/transthyretin-can-denature-by-an-alternative-pathway",
  "topic": "science",
  "section": "Science",
  "published": "2026-09-08T07:00:00.000Z",
  "source": {
    "name": "PNAS",
    "slug": "pnas",
    "url": "https://www.pnas.org/doi/abs/10.1073/pnas.2536532123?af=R"
  },
  "original_language": "en",
  "account": null,
  "summary": "Proceedings of the National Academy of Sciences, Volume 123, Issue 37, September 2026. SignificanceIt is surprising that transthyretin (TTR) has an aggregation pathway leading to organ system deterioration in humans, because it denatures very slowly in circulation at physiological pH, and denaturation is required for aggregation. A ...",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}