{
  "id": 774143,
  "title": "A novel TRPA1 gain-of-function variant associated with painful sensory neuropathy acts through a PIP2 gating mechanism.",
  "url": "https://urgent.news/2026/08/13/a-novel-trpa1-gain-of-function-variant-associated-with-painful",
  "topic": "culture",
  "section": "Culture",
  "published": "2026-08-13T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.08.13.744390v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "TRPA1 (transient receptor potential ankyrin 1) is a non-selective, calcium-permeable cation channel that mediates pain by detecting environmental irritants and thermal stimuli. Although the role of TRPA1 in modulating pain perception is relatively well established, so far only a few human TRPA1 variants (N855S and A172V) have been associated with inherited neuropathic pain disorders. Here, we…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}