{
  "id": 7705217,
  "title": "REN-former prioritizes candidate regulators of kidney disease-state transitions through single-cell foundation modeling and human genetics",
  "url": "https://urgent.news/2026/09/15/ren-former-prioritizes-candidate-regulators-of-kidney-disease-state",
  "topic": "science",
  "section": "Science",
  "published": "2026-09-15T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.09.10.746481v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "Background Acute kidney injury (AKI)-to-chronic kidney disease (CKD) transition is associated with dynamic changes in tubular cell state. However, conventional single-cell transcriptomic analyses primarily identify genes differentially expressed between disease states and do not directly evaluate genes associated with directional transitions between cellular states. Methods We developed…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}