{
  "id": 7705215,
  "title": "Substrate binding reorganizes the energetic landscape of Plasmodium falciparum hexose transporter PfHT1",
  "url": "https://urgent.news/2026/09/15/substrate-binding-reorganizes-the-energetic-landscape-of-plasmodium",
  "topic": "science",
  "section": "Science",
  "published": "2026-09-15T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.09.13.751325v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "Malaria parasites depend on the Plasmodium falciparum hexose transporter PfHT1 for sugar uptake, yet how substrate binding reshapes transporter energetics and kinetics of sugar transport remains poorly understood. Here, we investigate how glucose reorganizes the conformational landscape, transition pathways, and residue interaction network underlying membrane transport. Using over 800 s of…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}