{
  "id": 7594940,
  "title": "Right Resin, Right Order: A Two-Step Polishing Strategy for Bispecific Antibodies",
  "url": "https://urgent.news/2026/09/15/right-resin-right-order-a-two-step-polishing-strategy-for-bispecific",
  "topic": "health",
  "section": "Health & Medicine",
  "published": "2026-09-15T16:49:29.000Z",
  "source": {
    "name": "GEN Biotechnology",
    "slug": "gen-biotechnology",
    "url": "https://www.genengnews.com/multimedia/webinars/right-resin-right-order-a-two-step-polishing-strategy-for-bispecific-antibodies/"
  },
  "original_language": "en",
  "account": "Emily Gaither, a bioprocessing engineer at Thermo Fisher Scientific, discussed a two-step polishing strategy for bispecific antibodies (bsAbs) in a GEN webinar. Bispecific antibodies can present purification challenges due to product-related variants that closely resemble the desired heterodimer. Gaither emphasized the importance of selecting appropriate chromatography resins and optimizing complementary unit operations for efficient process development.\n\nThe webinar showcased a systematic approach to screening polishing resins, tailored to the unique characteristics of bsAbs. Gaither compared various process configurations and evaluated purity, recovery, and process-performance tradeoffs to determine the most effective polishing train. She highlighted key takeaways, including strategies for matching resin selectivity to impurities, the impact of resin selection on process performance, and the balancing act between purity, yield, loading, and robustness.\n\nThe presentation concluded with a live Q&A session, allowing attendees to engage with Gaither and gain further insights into this crucial aspect of bsAbs manufacturing. This approach ensures effective and efficient process development, addressing the unique challenges posed by bispecific antibodies.",
  "summary": "In this GEN webinar, our expert speaker, Emily Gaither, will present a systematic path from high-throughput resin screening to the selection and sequencing of two polishing steps, using emicizumab, an asymmetric IgG4 bsAb as a case study. The post Right Resin, Right Order: A Two-Step Polishing Strategy for Bispecific Antibodies appeared first on GEN - Genetic Engineering and Biotechnology News .",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}