{
  "id": 7461761,
  "title": "Structure-function analysis of PI3K signalling cascade base editing screens in cancer cells",
  "url": "https://urgent.news/2026/09/14/structure-function-analysis-of-pi3k-signalling-cascade-base-editing",
  "topic": "health",
  "section": "Health & Medicine",
  "published": "2026-09-14T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.09.08.748517v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "Knowledge of protein structure and function underpins rational drug discovery, yet many targets lack known selectively druggable sites. Furthermore, the identification of secondary druggable sites offers a strategy to overcome drug resistance. Fragment-based drug discovery (FBDD) can identify new ligandable binding pockets, though how to triage those with the ability to exert biologically…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}