{
  "id": 7461757,
  "title": "Profiling proteome-level amino acid substitutions in Alzheimer's disease brain tissue",
  "url": "https://urgent.news/2026/09/14/profiling-proteome-level-amino-acid-substitutions-in-alzheimers",
  "topic": "health",
  "section": "Health & Medicine",
  "published": "2026-09-14T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.09.08.750259v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "As the most prevalent neurodegenerative disorder worldwide, Alzheimer's disease (AD) remains incompletely understood at the proteome level. In particular, current studies on amino acid (AA) substitutions have predominantly relied on genomic and transcriptomic profiling. Proteome-scale AA substitutions remain largely uncharacterized. Nevertheless, alterations at the DNA and RNA levels cannot fully…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 2,
    "also_reported_by": [
      {
        "outlet": "Medical Xpress",
        "title": "Biodegradable drug-delivery nanoparticles curb brain plaque proteins and improve memory in Alzheimer's mice",
        "url": "https://urgent.news/2026/09/10/biodegradable-drug-delivery-nanoparticles-curb-brain-plaque-proteins",
        "published": "2026-09-10T12:40:06.000Z"
      }
    ]
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}