{
  "id": 7382940,
  "title": "Quantitative Modelling of Amyloid-β Dynamics in Brain, CSF, and Plasma During Sleep and Wakefulness",
  "url": "https://urgent.news/2026/09/14/quantitative-modelling-of-amyloid-dynamics-in-brain-csf-and-plasma",
  "topic": "science",
  "section": "Science",
  "published": "2026-09-14T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.09.07.749991v1?rss=1"
  },
  "original_language": "en",
  "account": "Amyloid-beta (A{beta}) accumulation in the brain is associated with Alzheimer's disease. Typically, A{beta} levels surge during wakefulness and decrease during sleep. However, the impact of sleep disturbances on A{beta} dynamics remains uncertain. To investigate this, researchers created a model considering brain, cerebrospinal fluid (CSF), and plasma. The model accurately reflected the 24-hour A{beta}42 oscillations observed in CSF (660-760 pg/mL) and plasma (15-19 pg/mL). Additionally, it forecasted brain A{beta} dynamics. Data from indwelling lumbar catheters revealed higher CSF A{beta}42 levels in the second morning after a full night of sleep compared to the first morning. The model suggests this elevated level is likely due to repeated CSF sampling, which alters A{beta} levels through pressure-mediated changes in CSF, impaired sleep-associated clearance, or a combination of both factors. These insights provide a framework for understanding A{beta} regulation, emphasizing sleep's protective role and the necessity for non-invasive measurement methods.",
  "summary": "Amyloid-beta (A{beta}) accumulation in the brain is linked to Alzheimer's disease. In healthy individuals, A{beta} rises during wakefulness and is cleared during sleep, yet the effects of sleep disturbances on the A{beta} dynamics are unclear. We developed a model, incorporating brain, cerebrospinal fluid (CSF), and plasma, to investigate the A{beta} dynamics along the sleep-wake cycles. The…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}