{
  "id": 7337198,
  "title": "Nanoparticle size governs engagement with myeloid cells and hitchhiking to hematopoietic organs in myeloproliferative neoplasms",
  "url": "https://urgent.news/2026/09/14/nanoparticle-size-governs-engagement-with-myeloid-cells-and",
  "topic": "science",
  "section": "Science",
  "published": "2026-09-14T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.09.07.749819v1?rss=1"
  },
  "original_language": "en",
  "account": "Nanoscale engineering of nanoparticles plays a pivotal role in their effectiveness within the body, encompassing prolonged circulation times, strategic distribution profiles, and regulated interactions with the immune system. While these factors are well-documented in solid tumor treatment, their impact on hematological malignancies remains less understood. This study delves into the role of liposome size in enhancing biodistribution and cellular uptake in hematopoietic tissues - bone marrow (BM) and spleen - in the context of JAK2V617F myeloproliferative neoplasms (MPN).\n\nUtilizing a high-throughput liposome production system in conjunction with a Design-of-Experiments (DoE) framework, the research team generated liposomes of varying sizes - small, medium, and large. These nanoparticles underwent ex vivo analysis using blood samples from healthy donors and MPN patients, followed by in vivo investigations in a mouse model genetically engineered to exhibit JAK2V617F MPN. Organ-level accumulation was evaluated through hybrid fluorescence/computed tomography (FLT/CT) imaging, while cellular uptake was assessed using flow cytometry.\n\nResults indicate that increasing liposome size led to improved delivery to both the spleen and BM, with the largest liposomes demonstrating the highest accumulation in these organs. Extensive cellular analysis corroborated these in vivo observations, revealing that large liposomes were taken up more significantly by monocytes and granulocytes in both spleen and BM. Late post-injection, the liposomal accumulation in BM was twice as high compared to spleen and peripheral blood, underscoring the progressive buildup and retention in the BM, as opposed to elimination in clearance organs and circulation at these time-points. Interestingly, among BM mature myeloid cells, neutrophils showed the highest nanoparticle uptake, suggesting their potential to engulf material circulating in the body and transport it to malignant or inflamed regions.\n\nThese findings underscore the potential of continuous flow manufacturing techniques to rapidly produce nanoparticles with tailored properties crucial for directing biodistribution towards hematopoietic tissues and myeloid immune cells. By elucidating the mechanistic underpinnings of nanoparticle behavior within hematopoietic compartments, this research advances our understanding of nanomedicine performance in vivo, emphasizing particle size as a key quality attribute that can be optimized and controlled to enhance targeted delivery to myeloid cells for the treatment of hematological malignancies.",
  "summary": "Nanoparticle design principles contribute to desirable in vivo performance, including prolonged circulation, desirable biodistribution profiles, and tuned interactions with the immune system. The importance of these variables, although well-established in solid tumors, remains elusive in the context of hematological malignancies. Here, we investigated the influence of liposome size on…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}