{
  "id": 7195367,
  "title": "Zipalertinib plus chemo shows survival benefit in lung cancer trial",
  "url": "https://urgent.news/2026/09/13/zipalertinib-plus-chemo-shows-survival-benefit-in-lung-cancer-trial",
  "topic": "health",
  "section": "Health & Medicine",
  "published": "2026-09-13T23:20:40.000Z",
  "source": {
    "name": "Investing.com",
    "slug": "investing-com",
    "url": "https://www.investing.com/news/company-news/zipalertinib-plus-chemo-shows-survival-benefit-in-lung-cancer-trial-93CH-4898765"
  },
  "original_language": "en",
  "account": null,
  "summary": "Taiho Oncology, Inc., Taiho Pharmaceutical Co., Ltd., and Cullinan Therapeutics, Inc. have announced promising results from a Phase 3 trial evaluating the combination of zipalertinib, a targeted therapy, and chemotherapy in first-line treatment of patients with non-small cell lung cancer (NSCLC) carrying the EGFR exon 20 insertion mutation. The REZILIENT3 trial, presented at the World Conference on Lung Cancer in Seoul, South Korea, met its primary endpoint of progression-free survival. The combination therapy provided a median progression-free survival improvement of 6.0 months compared to chemotherapy alone, with a hazard ratio of 0.50 (95% CI, 0.34-0.73; P=0.00015). Median progression-free survival was 14.5 months for the combination versus 8.5 months for chemotherapy alone. The trial enrolled 279 advanced NSCLC patients with the specific genetic mutation, randomly assigning them to receive either the combination therapy or chemotherapy alone.",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 2,
    "also_reported_by": [
      {
        "outlet": "Medical Xpress",
        "title": "Zipalertinib plus chemotherapy significantly extends progression-free survival in first-line EGFR lung cancer",
        "url": "https://urgent.news/2026/09/14/zipalertinib-plus-chemotherapy-significantly-extends-progression-free",
        "published": "2026-09-14T01:50:10.000Z"
      }
    ]
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}