{
  "id": 719221,
  "title": "Sequential division of labor between PAXX and XLF drives NHEJ synaptic complex stability and maturation",
  "url": "https://urgent.news/2026/08/12/sequential-division-of-labor-between-paxx-and-xlf-drives-nhej",
  "topic": "science",
  "section": "Science",
  "published": "2026-08-12T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.08.10.743781v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "DNA double-strand breaks (DSBs) are primarily repaired by non-homologous end joining (NHEJ), which tethers and ligates DNA ends within a synaptic complex. PAXX is an NHEJ accessory factor related to XRCC4 and XLF, but its mechanistic role and genetic interaction with XLF are unclear. Using biochemical assays and single-molecule imaging within Xenopus laevis egg extracts and human cell assays, we…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}