{
  "id": 6742017,
  "title": "Gene repertoire expansion and cis-regulatory diversification shaped 26S proteasome evolution within a proteostasis-centered network",
  "url": "https://urgent.news/2026/09/11/gene-repertoire-expansion-and-cis-regulatory-diversification-shaped",
  "topic": "science",
  "section": "Science",
  "published": "2026-09-11T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.09.09.750301v1?rss=1"
  },
  "original_language": "en",
  "account": "The 26S proteasome plays a crucial role in maintaining proteostasis across eukaryotes. While its core functionality is conserved, the evolution of its subunits and regulatory feedback mechanisms remains unclear. To unravel this, researchers performed a comprehensive study on plant 26S proteasomes. They discovered that proteasome gene repertoires expanded independently in different plant lineages. Paralogs exhibited alterations in post-translational modification sites and transcriptional responses to environmental changes. Promoter analysis unveiled significant diversification of proteasome-associated cis-regulatory elements. These findings led to the identification of telomere repeat-binding proteins as new transcription regulators of proteasome genes in Arabidopsis thaliana, interacting with the PRCE motif. Evolutionary rate comparisons unveiled a conserved network of proteasome-associated components, all linked through shared cis-elements that regulate cellular proteostasis. This study reveals that plant 26S proteasome is governed by a regulatory framework that integrates conserved mechanisms, unique innovations, and stress-responsive adaptations, emphasizing the central role of this complex in cellular health.",
  "summary": "The 26S proteasome is essential for proteostasis and constitutes one of the most conserved molecular machineries in eukaryotes. Its homeostasis is maintained by a mechanistically conserved feedback loop involving kingdom-specific components. Yet, how the proteasome subunits and associated regulatory feedback loop have evolved to accommodate ever-changing cellular context is poorly understood.…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}