{
  "id": 6672298,
  "title": "A Single-cell Spatiotemporal Atlas Encoding Age-dependent Evolution of the Ischemic Penumbra",
  "url": "https://urgent.news/2026/09/10/a-single-cell-spatiotemporal-atlas-encoding-age-dependent-evolution",
  "topic": "science",
  "section": "Science",
  "published": "2026-09-10T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.09.08.750251v1?rss=1"
  },
  "original_language": "en",
  "account": "The prevalence of stroke escalates with age, exacerbating detrimental neurological outcomes. The ischemic penumbra, a critical therapeutic target, exhibits an incompletely understood age-dependent molecular profile. Researchers generated a spatiotemporal transcriptomic atlas of the post-stroke penumbra in both young (3-4 month-old) and aged (19-20 month-old) mice at two time points following transient focal cerebral ischemia: acute (day 3) and chronic (day 14). By combining spatial transcriptomics with single-cell RNA sequencing, the researchers identified a persistent transcriptomic penumbra (TP) observable for up to 14 days post-stroke, surpassing the timeframe typically inferred by traditional imaging techniques.\n\nThe aging process significantly influenced the TP organization, leading to dysregulated energy metabolism, impaired neurovascular repair, diminished pro-reparative cell-cell communication, and extensive remodeling of transcriptional regulatory networks. Utilizing this atlas, the team pinpointed regulatory hub genes whose functional disruption could concurrently mitigate several age-related pathological pathways. The assembled data delineate the molecular architecture of the aging post-stroke penumbra and furnish a publicly available platform for mechanistic exploration and therapeutic target identification, with the ultimate goal of enhancing recovery following stroke.",
  "summary": "Aging is the predominant risk factor for stroke and a major driver of poor neurological recovery. Although the ischemic penumbra represents a key therapeutic target, its age-dependent molecular landscape remains poorly understood. Here, we generated a spatiotemporal transcriptomic atlas of the post-stroke penumbra in young (3-4 months) and aged (19-20 months) mice at acute (day 3) and chronic…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}