{
  "id": 6651587,
  "title": "Remodelling of chromatin architecture and super-enhancer landscape in lamin A/C depleted HGSOC",
  "url": "https://urgent.news/2026/09/10/remodelling-of-chromatin-architecture-and-super-enhancer-landscape-in",
  "topic": "science",
  "section": "Science",
  "published": "2026-09-10T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.09.07.749802v1?rss=1"
  },
  "original_language": "en",
  "account": "Lamins, intermediate filament proteins in the nucleus, maintain structural integrity by interacting with chromatin. A- and B-type lamins anchor the genome at the nuclear lamina as heterochromatic domains. However, A-type lamins extend into the nuclear core, implying diverse roles in chromatin organization and regulation. Studies on lamin B1 depletion revealed LADs detaching from the nuclear periphery, resulting in altered chromatin distribution while TADs retained their structural integrity. This study is the first to examine the impact of lamin A/C depletion on chromatin organization in high-grade serous ovarian cancer (HGSOC). The findings demonstrate significant detethering of gene-poor chromatin from the periphery and a switch from active (A) to inactive (B) chromatin compartments. This chromatin remodeling was linked to a rewiring of oncogenic super-enhancer elements, as evidenced by differential gene expression. The overall analysis supports reduced cellular proliferation following lamin A/C knockdown. This conclusion is reinforced by the diminished proliferative potential of spheroids outside the cell and tumours in a mouse xenograft model.",
  "summary": "Lamins are nuclear intermediate filament proteins that maintain nuclear architecture through interactions with the chromatin. The A- and B-type lamins tether the genome at the peripheral lamina underlying the inner nuclear membrane in the form of heterochromatic lamina-associated domains (LADs). However, LADs associated with A-type lamins are confined not only to lamina but also to the nuclear…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}