{
  "id": 6313815,
  "title": "ADCs, mAbs, CAR Ts: One Bioluminescent Platform Measures Them All",
  "url": "https://urgent.news/2026/09/08/adcs-mabs-car-ts-one-bioluminescent-platform-measures-them-all",
  "topic": "health",
  "section": "Health & Medicine",
  "published": "2026-09-08T19:28:06.000Z",
  "source": {
    "name": "GEN Biotechnology",
    "slug": "gen-biotechnology",
    "url": "https://www.genengnews.com/sponsored/adcs-mabs-car-ts-one-bioluminescent-platform-measures-them-all/"
  },
  "original_language": "en",
  "account": null,
  "summary": "The Promega HiBiT Target Cell Killing (TCK) platform is a bioluminescent cell-based system designed to measure cytotoxicity with specificity, simplicity, and sensitivity during immunotherapy development. The platform supports the assessment of four killing mechanisms—CAR-T cell-mediated killing, antibody-dependent cellular cytotoxicity (ADCC), T cell-dependent cellular cytotoxicity (TDCC), and antibody-dependent cellular phagocytosis (ADCP). The HiBiT TCK platform leverages gain, not loss, of signal detection, which avoids kinetic complications of loss-of-signal assays and produces robust signal-to-noise with minimal cell numbers. The platform includes a growing library of off-the-shelf assay components, including functionally tested cell lines for blood cancer targets and solid tumor targets. Custom tailored target cells can also be created using ViaScript mRNA transfection.",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}