{
  "id": 6283178,
  "title": "Hippocampal/medial temporal sclerosis is associated with clinical severity, regional TDP-43, and hippocampal atrophy in Alzheimer disease",
  "url": "https://urgent.news/2026/09/08/hippocampal-medial-temporal-sclerosis-is-associated-with-clinical",
  "topic": "health",
  "section": "Health & Medicine",
  "published": "2026-09-08T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.09.03.749099v1?rss=1"
  },
  "original_language": "en",
  "account": "Alzheimer disease neuropathologic change does not fully explain clinical severity in patients, indicating the presence of other coexisting pathologies. Researchers analyzed data from a large autopsy cohort to study the role of hippocampal/medial temporal sclerosis (HS/MTL sclerosis) in clinical severity, regional TDP43 involvement, and hippocampal atrophy. The study identified that HS/MTL sclerosis was present in 13% of cases and was linked to higher dementia staging instrument severity scores, both in non-AD and AD populations. In particular, HS/MTL sclerosis was associated with a greater regional TDP43 topography in later versions of the study and greater hippocampal atrophy, suggesting that it co-occurs with both AD pathology and TDP43 involvement. Notably, among AD cases assessed near the end of life, participants without HS/MTL sclerosis were more likely to have non-dementia status compared to those with HS/MTL sclerosis. The presence of HS/MTL sclerosis was linked to greater clinical severity in both AD and non-AD cases, highlighting its importance in understanding clinical outcomes in Alzheimer's disease.",
  "summary": "Alzheimer disease neuropathologic change (ADNC) does not fully explain clinical severity, suggesting important contributions from coexisting pathologies. We examined major co-pathologies in a multicenter autopsy cohort, focusing on hippocampal/medial temporal sclerosis (HS/MTL sclerosis), clinical severity, regional TDP43 topography, clinical status near death, and gross hippocampal atrophy. We…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}