{
  "id": 6283176,
  "title": "Heterogeneity of Brain Dynamics in Genetic and Psychiatric Conditions",
  "url": "https://urgent.news/2026/09/08/heterogeneity-of-brain-dynamics-in-genetic-and-psychiatric-conditions",
  "topic": "science",
  "section": "Science",
  "published": "2026-09-08T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.09.01.748394v1?rss=1"
  },
  "original_language": "en",
  "account": "The heterogeneity of psychiatric conditions and their relationship to shared neurophysiological changes remains uncertain. Researchers collected high-density electroencephalogram (hd-EEG) resting-state recordings from 4,812 individuals aged 5 months to 66 years, encompassing 11 psychiatric conditions, a range of rare genetic variants, and typically developing (TD) participants. They mapped normative developmental trajectories of source-space EEG concerning spectral organization, connectivity, and signal complexity. Psychiatric conditions exhibited minor deviations, indicating a shared transdiagnostic profile. However, single rare variants displayed significantly larger, distinct, and occasionally mirror-opposite signatures, which merged with the psychiatric profile upon pooling. Autism Spectrum Disorder demonstrated some of the smallest group-level effects but the most substantial individual deviations, suggesting directionally inconsistent alterations. EEG deviations followed a cortical gradient, with more pronounced effects in sensorimotor regions. The study reveals that sample sizes of hundreds are necessary for robust associations with psychiatric diagnoses. This interactive open resource supplies normative scores to serve as benchmarks for future research.",
  "summary": "Whether the heterogeneity of psychiatric conditions converges on shared neurophysiological alterations or translates into distinct signatures remains unclear. We assembled high-density electroencephalogram (hd-EEG) resting-state recordings from 4,812 individuals aged 5 months to 66 years across 11 psychiatric conditions, a broad spectrum of rare genetic variants, and typically developing (TD)…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}