{
  "id": 6038885,
  "title": "Brain signaling mechanism may explain clozapine weight gain",
  "url": "https://urgent.news/2026/09/06/brain-signaling-mechanism-may-explain-clozapine-weight-gain",
  "topic": "health",
  "section": "Health & Medicine",
  "published": "2026-09-06T21:00:08.000Z",
  "source": {
    "name": "Medical Xpress",
    "slug": "medical-xpress",
    "url": "https://medicalxpress.com/news/2026-09-brain-mechanism-clozapine-weight-gain.html"
  },
  "original_language": "en",
  "account": "Researchers at UT Southwestern Medical Center have discovered a brain signaling pathway that contributes to the weight gain associated with clozapine, an antipsychotic medication used to treat treatment-resistant schizophrenia. The findings, published in Nature Communications, suggest that blocking this pathway could potentially reduce the metabolic side effects of clozapine.",
  "summary": "Researchers at UT Southwestern Medical Center have identified a key brain signaling pathway that appears to drive the substantial weight gain often associated with clozapine, a widely used antipsychotic medication. The preclinical findings, published in Nature Communications, point to a potential way to reduce the metabolic side effects of this medication, commonly prescribed for patients with…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}