{
  "id": 5996126,
  "title": "Role of gut epithelial-cell derived transglutaminase 2 in the formation of celiac disease autoantibodies",
  "url": "https://urgent.news/2026/09/06/role-of-gut-epithelial-cell-derived-transglutaminase-2-in-the",
  "topic": "science",
  "section": "Science",
  "published": "2026-09-06T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.09.01.748464v1?rss=1"
  },
  "original_language": "en",
  "account": "A recent study has shed light on the potential role of gut epithelial-cell derived transglutaminase 2 (TG2) in the development of celiac disease autoantibodies. The research indicates that TG2-gluten complexes may facilitate the interaction between gluten-specific CD4+ T cells and TG2-specific B cells, thereby contributing to the autoimmune response.\n\nTo explore this hypothesis, scientists generated mice with the ability to produce TG2 fused to a deamidated gluten peptide (DGP) containing a T-cell epitope. When this TG2-DGP fusion protein was expressed in intestinal epithelial cells (IECs) and released into the intestinal lumen, it proved immunogenic in mice with activated gluten-specific CD4+ T cells and naive TG2-specific B cells. The resulting production of intestinal and systemic anti-TG2 autoantibodies supports the idea that TG2, when derived from intestinal epithelial cells, plays a pathogenic role in driving anti-TG2 autoimmunity in celiac disease.",
  "summary": "Formation of autoantibodies to transglutaminase 2 (TG2) in celiac disease likely involves TG2-gluten complexes that allow gluten-specific CD4+ T cells to provide help to TG2-specific B cells. To investigate whether TG2 derived from intestinal epithelial cells (IECs) contributes to this process, we generated mice with inducible IEC-specific expression of TG2 fused to a deamidated gluten peptide…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}