{
  "id": 5973354,
  "title": "Disabling a gene brake in pancreatic cells unlocks insulin-producing potential",
  "url": "https://urgent.news/2026/09/06/disabling-a-gene-brake-in-pancreatic-cells-unlocks-insulin-producing",
  "topic": "health",
  "section": "Health & Medicine",
  "published": "2026-09-06T12:00:01.000Z",
  "source": {
    "name": "Medical Xpress",
    "slug": "medical-xpress",
    "url": "https://medicalxpress.com/news/2026-09-disabling-gene-pancreatic-cells-insulin.html"
  },
  "original_language": "en",
  "account": "Scientists from Harvard Medical School have discovered a method to transform pancreatic cells into insulin-producing cells, potentially revolutionizing the treatment of type 1 and type 2 diabetes. The team identified a gene called ALDH3B2 that acts as a molecular brake, preventing pancreatic duct cells from developing into beta-like cells. By turning off this gene using advanced CRISPR gene-editing technology, the researchers observed a significant increase in the transformation rate from 1% to approximately 8.5% in human cells. This breakthrough could lead to a more efficient and personalized approach to generating insulin-producing cells, eliminating the need for donor transplants and the complications associated with immune rejection. The discovery was published in Science Translational Medicine and offers hope for improving the quality of life for millions of diabetes patients worldwide.",
  "summary": "Type 1 and 2 diabetes are ultimately caused by a shortage of beta (β) cells, which are present in the pancreas and produce insulin to control blood sugar. Researchers from Harvard Medical School found that they can tweak a gene and turn a patient's own pancreatic cells into insulin-producing cells.",
  "key_points": [
    "Scientists at Harvard Medical School discovered a gene brake in pancreatic cells.",
    "ALDH3B2 gene prevents pancreatic duct cells from developing into beta-like cells.",
    "CRISPR gene-editing technology increased transformation rate from 1% to 8.5%."
  ],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}