{
  "id": 5715150,
  "title": "Autoantibodies from recovered Guillain-Barre syndrome patients exhibit altered effector functions that prevent subsequent neuron degeneration",
  "url": "https://urgent.news/2026/09/04/autoantibodies-from-recovered-guillain-barre-syndrome-patients",
  "topic": "health",
  "section": "Health & Medicine",
  "published": "2026-09-04T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.08.31.748457v1?rss=1"
  },
  "original_language": "en",
  "account": "Guillain-Barre syndrome (GBS) is an autoimmune disorder that often follows an infection, most commonly Campylobacter jejuni. This triggers antibodies that resemble bacterial ganglioside-mimicking lipooligosaccharides, which in turn cross-react with human neuronal gangliosides, resulting in neuropathy. After recovery, patients often have high levels of anti-ganglioside antibodies for over a decade. However, these antibodies no longer cause neuropathy when tested using a human pluripotent stem cell-derived sensory neuron model with human complement. The study reveals differences in IgG subclass and glycoform between acute and recovered GBS patient sera, encompassing anti-inflammatory modifications on isolated anti-GM1 ganglioside antibodies. The findings suggest that GBS patients develop non-pathogenic variants of autoantibodies that are unable to damage their neurons but may still offer protection against C. jejuni infection.",
  "summary": "Guillain-Barre syndrome (GBS) is an autoimmune polyneuropathy that is the leading cause of nonpoliovirus-associated acute flaccid paralysis worldwide. In most cases, GBS occurs following an infection, most commonly Campylobacter jejuni, through the induction of antibodies recognizing bacterial ganglioside-mimicking lipooligosaccharides that cross-react with human neuronal gangliosides. This…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}