{
  "id": 5463575,
  "title": "Single-cell multi-omics maps clonal IEL expansion and epithelial remodelling in refractory coeliac disease",
  "url": "https://urgent.news/2026/09/03/single-cell-multi-omics-maps-clonal-iel-expansion-and-epithelial",
  "topic": "science",
  "section": "Science",
  "published": "2026-09-03T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.08.30.747985v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "Background Refractory coeliac disease type 1 (RCD1) lacks defining molecular markers, and the immune and epithelial mechanisms sustaining intestinal injury remain poorly understood. Objective To define the clonal immune and epithelial states that distinguish RCD1 from active coeliac disease (ACD) and determine their spatial organisation in the duodenal mucosa. Design We integrated single-cell RNA…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}