{
  "id": 5463574,
  "title": "Cellular integration of surface and nutrient signals during the early stage of filamentous growth in Saccharomyces cerevisiae",
  "url": "https://urgent.news/2026/09/03/cellular-integration-of-surface-and-nutrient-signals-during-the-early",
  "topic": "science",
  "section": "Science",
  "published": "2026-09-03T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.09.02.748872v1?rss=1"
  },
  "original_language": "en",
  "account": "Budding yeast cells have the ability to shift from a flat, vegetative state to a filamentous growth form under specific environmental signals. S. cerevisiae, a model organism for studying this process, connects it to the virulence displayed by numerous fungal pathogens. A key aspect of filamentation in S. cerevisiae is the creation of pseudohyphal cells, which are elongated and grow in a polarized pattern.\n\nTo observe this morphological change in real-time, we set up a live-cell imaging assay and created fluorescent reporters to monitor the activity of different signaling pathways during the initial 10 hours of filamentous growth development. Through this method, we were able to pinpoint the specific stimulus that triggers the filamentous growth Mitogen-Activated Protein Kinase (fgMAPK) pathway, which had previously remained unidentified. Our findings reveal that the fgMAPK cascade detects mechanical cues and gets activated when cells are growing on a solid surface.\n\nFurthermore, we discovered that the stimulation of the Gln3 transcription factor, regulated by the TOR pathway under low ammonium conditions, is associated with the elongation of the cells during this early stage of filamentous growth.",
  "summary": "Budding yeast cells can transition from vegetative to filamentous growth under specific environmental stimuli. Saccharomyces cerevisiae has served as a model to understand this process, which is linked to the virulence of many fungal pathogens. One manifestation of filamentation in S. cerevisiae is the formation of pseudohyphal cells, which are elongated and divide in a polarized manner. Here, we…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}