{
  "id": 5463562,
  "title": "Tumour rewires host tryptophan metabolism to promote organism-wide immune suppression",
  "url": "https://urgent.news/2026/09/03/tumour-rewires-host-tryptophan-metabolism-to-promote-organism-wide",
  "topic": "health",
  "section": "Health & Medicine",
  "published": "2026-09-03T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.09.02.748262v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "How tumour genotype reshapes systemic metabolism to drive immune tolerance and tumour progression remains unclear. Here, we show that Pten-deficient Drosophila tumours reprogram host tryptophan metabolism, triggering systemic and local changes in immune and stromal compartments to foster tolerance. Tumour-derived nitric oxide activates the kynurenine pathway in liver-like tissue, selectively…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}