{
  "id": 5405996,
  "title": "Ligand-binding/transcriptional repressor domain-deficient REV-ERBβ inhibits dendrite and spine formation of newborn adult hippocampal neurons",
  "url": "https://urgent.news/2026/09/03/ligand-binding-transcriptional-repressor-domain-deficient-rev-erb",
  "topic": "science",
  "section": "Science",
  "published": "2026-09-03T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.08.29.746924v1?rss=1"
  },
  "original_language": "en",
  "account": "REV-ERBβ, a transcriptional repressor of nuclear receptors, plays a crucial role in regulating the circadian rhythm and the proliferation, differentiation, and maturation of neurons. Dysregulation of the circadian rhythm is linked to neuropsychiatric disorders, and activation of REV-ERBs can lead to anxiolytic behavior in mice. Moreover, hippocampal neurogenesis, which is essential for the effects of antidepressants, is influenced by REV-ERBβ. However, the specific role of REV-ERBβ in adult hippocampal neurogenesis at the single-cell level in vivo has not been well understood. This study aimed to investigate this role by examining the protein localization of REV-ERBβ in the subgranular zone of the hippocampal dentate gyrus (DG) in adult mice. The researchers found that REV-ERBβ mainly localized in NeuN-positive neurons. To further explore its effects, a dominant negative form of REV-ERBβ lacking the C-terminal region was expressed in newborn neurons in the hippocampal DG of adult mice using a retroviral vector. After 4 weeks, the study observed that the expression of this dominant negative form inhibited dendrite outgrowth and branching, and decreased dendritic spine formation in the newborn neurons. These findings reveal a new role for REV-ERBβ in adult hippocampal neurogenesis at the single-cell level, providing valuable insights into the relationship between neurogenesis in the adult brain and psychiatric disorders.",
  "summary": "REV-ERB{beta} is a transcriptional repressor of nuclear receptors that regulates the circadian rhythm and plays an important role in regulation of the proliferation, differentiation, and maturation of neurons. Dysregulation of the circadian rhythm has been associated with neuropsychiatric disorders, and activation of REV-ERBs can induce anxiolytic behavior in mice. Furthermore, hippocampal…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}