{
  "id": 522760,
  "title": "Ferumoxytol dynamic contrast-enhanced MRI for in vivo longitudinal cotyledon perfusion assessment with pathology correlation in a rhesus macaque thrombotic injury model",
  "url": "https://urgent.news/2026/08/10/ferumoxytol-dynamic-contrast-enhanced-mri-for-in-vivo-longitudinal",
  "topic": "health",
  "section": "Health & Medicine",
  "published": "2026-08-10T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.08.04.742075v1?rss=1"
  },
  "original_language": "en",
  "account": "The introduction highlights the importance of understanding the relationship between placental perfusion, pathology, and pregnancy outcomes. Ferumoxytol dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is introduced as a promising method to noninvasively identify cotyledons throughout gestation and measure changes in longitudinal cotyledon-specific perfusion. Intraplacental injection of bioactive fibrin sealant is used to model thrombotic placental injury, allowing for further assessment of cotyledon-level relationships between perfusion and significant injury.\n\nThe study involved 13 pregnant rhesus macaques, with some receiving saline injections and others receiving fibrin sealant injections at gestational day 101. DCE-MRI was performed at gestational days 100, 115, and 145. The contrast arrival time was used to segment placental perfusion domains, which were then matched to cotyledons identified through cesarean section tissue collection. Cotyledon perfusion was quantified longitudinally and correlated with cotyledon-specific histopathology.\n\nThe results showed that all pregnancies were successfully carried to term. Fibrin sealant injections led to significantly higher levels of placental pathology compared to saline controls. The MRI-derived perfusion domains were largely consistent across gestation and largely corresponded with term cotyledons, with successful pairing of perfusion and pathology in 153 cotyledons. Longitudinal changes in cotyledon perfusion were significantly correlated with villous agglutination injuries. The study concludes that noninvasively tracking placental cotyledon perfusion using ferumoxytol DCE-MRI is feasible, and the rhesus macaque thrombotic injury model demonstrated efficacy. The positive correlations between perfusion and pathology suggest intrinsic placental regulatory mechanisms and functional plasticity, paving the way for future translational studies and validation of ex vivo cotyledon perfusion models.",
  "summary": "Introduction While placental perfusion and pathology jointly affect pregnancy outcomes, cotyledon-specific perfusion across gestation and its correlation with local injury is not yet well understood. Ferumoxytol dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) offers a promising way to noninvasively identify cotyledons across gestation and quantify longitudinal cotyledon-specific…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}