{
  "id": 5115572,
  "title": "Structure and operating principles of a monkeypox virus replisome",
  "url": "https://urgent.news/2026/09/02/structure-and-operating-principles-of-a-monkeypox-virus-replisome",
  "topic": "science",
  "section": "Science",
  "published": "2026-09-02T00:00:00.000Z",
  "source": {
    "name": "Nature",
    "slug": "nature",
    "url": "https://www.nature.com/articles/s41586-026-10937-2"
  },
  "original_language": "en",
  "account": null,
  "summary": "Nature, Published online: 02 September 2026; doi:10.1038/s41586-026-10937-2 During replisome assembly of monkeypox virus, the hexameric helicase–primase E5 undergoes large-scale conformational changes that allow two of its primase domains to interact with the polymerase F8 thumb domain and A22 subunit, activating the helicase–primase.",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}