{
  "id": 4927451,
  "title": "OMICON: a community resource for studying gene coexpression networks in normal and neoplastic human brain samples",
  "url": "https://urgent.news/2026/09/01/omicon-a-community-resource-for-studying-gene-coexpression-networks",
  "topic": "science",
  "section": "Science",
  "published": "2026-09-01T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.08.25.747141v1?rss=1"
  },
  "original_language": "en",
  "account": "Genome-wide coexpression analysis of intact tissue samples is a valuable method for discovering consistent indicators of cell types and states across large groups of individuals, cells, and transcripts. However, constructing gene coexpression networks and comparing outcomes from separate analyses can be challenging. To tackle these issues, we created OMICON (https://theomicon.ucsf.edu) for researching human brain gene coexpression networks. OMICON houses gene expression data from 17,000 normal and malignant human brain samples, all accompanied by standardized metadata. By examining various independent datasets, we discovered 250,000 gene coexpression modules, which were further analyzed and compared using enrichment analysis with 40,000 gene sets. Users can easily access all modules through an advanced search engine that allows filtering by genes, metadata, and enrichment results. Additionally, an interactive workflow visualization tool enables users to explore analyses, while the @mention functionality facilitates communication within the OMICON community, promoting collaborative research on human brain gene coexpression networks.",
  "summary": "Genome-wide coexpression analysis of intact tissue samples is a powerful approach for identifying reproducible signatures of cell types and states, since it can survey vast numbers of individuals, cells, and transcripts. However, it can be difficult to optimize gene coexpression network construction and compare results from independent analyses. To address these challenges, we developed OMICON…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}