{
  "id": 4857536,
  "title": "Chemosensory ERP Suggest Peripherally Driven Olfactory-Trigeminal Interactions in Healthy Older Adults",
  "url": "https://urgent.news/2026/09/01/chemosensory-erp-suggest-peripherally-driven-olfactory-trigeminal",
  "topic": "science",
  "section": "Science",
  "published": "2026-09-01T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.08.25.746692v1?rss=1"
  },
  "original_language": "en",
  "account": "A study investigated the relationship between the olfactory and trigeminal systems in older adults, revealing that these systems interact primarily through peripheral mechanisms. The research involved 44 healthy individuals, aged 66.3 ± 4.6 years, with 29 of them being women. The participants underwent four conditions: pure trigeminal stimulation using carbon dioxide (CO2), pure olfactory stimulation using 2-phenylethanol (PEA), ipsilateral co-stimulation with both CO2 and PEA in the same nostril, and contralateral co-stimulation with CO2 and PEA in opposite nostrils. The findings showed that ipsilateral co-stimulation enhanced trigeminal localization performance and led to larger late positive component amplitudes in the electrophysiological responses. These results suggest that the olfactory-trigeminal interactions in elderly individuals are primarily driven by peripheral mechanisms rather than central processes. Additionally, the study provides normative chemosensory event-related potential (CSERP) data for healthy older adults.",
  "summary": "The olfactory and intranasal trigeminal systems interact closely, influencing chemosensory perception, yet the mechanisms underlying their interaction remain poorly understood and have been studied mainly in young adults. We aimed to characterize olfactory-trigeminal interactions in aging by comparing electrophysiological and behavioral responses under ipsilateral and contralateral…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}