{
  "id": 4710969,
  "title": "Estimated glucose disposal rate inversely linked to benign prostatic hyperplasia",
  "url": "https://urgent.news/2026/08/31/estimated-glucose-disposal-rate-inversely-linked-to-benign-prostatic",
  "topic": "science",
  "section": "Science",
  "published": "2026-08-31T20:30:08.000Z",
  "source": {
    "name": "Medical Xpress",
    "slug": "medical-xpress",
    "url": "https://medicalxpress.com/news/2026-08-glucose-disposal-inversely-linked-benign.html"
  },
  "original_language": "en",
  "account": "A recent study published in The Aging Male has found a negative link between estimated glucose disposal rate (eGDR) and benign prostatic hyperplasia (BPH) in both American and Chinese populations. The research, conducted by Haowen Liang and colleagues from Liuzhou Traditional Chinese Medical Hospital, analyzed data from the China Health and Retirement Longitudinal Study and the National Health and Nutrition Examination Survey, involving a total of 7,845 participants.\n\nThe study revealed a significant inverse relationship between eGDR and BPH risk, confirmed by a linear relationship observed in a restricted cubic spline analysis of both datasets. This association remained consistent across various subgroups within the study populations. Notably, the effect of eGDR on BPH risk was found to be mediated by monocytes at a rate of 15.14% in the U.S. cohort.\n\nThe findings suggest that eGDR may serve as a valuable indicator of insulin resistance, which could aid in the risk stratification of BPH. This adds to the growing body of knowledge on the relationship between insulin resistance and BPH development. The authors propose that managing central obesity and reducing chronic inflammation linked to insulin resistance may help lower the incidence of BPH. Furthermore, they highlight the monocyte inflammatory pathway as a potential therapeutic target for addressing BPH.",
  "summary": "There is a negative link between estimated glucose disposal rate (eGDR) and benign prostatic hyperplasia (BPH) in men, according to a study published online Aug. 25 in The Aging Male.",
  "key_points": [
    "Negative link found between eGDR and BPH risk in both American and Chinese populations",
    "Significant inverse relationship confirmed by linear analysis in restricted cubic spline",
    "eGDR mediates BPH risk through monocytes at 15.14% in U.S. cohort"
  ],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}