{
  "id": 4691128,
  "title": "Endocrine Neural Interactions Regulate Antral CCK2R+ Stem Cells in Gastric Inflammation and Preneoplasia",
  "url": "https://urgent.news/2026/08/31/endocrine-neural-interactions-regulate-antral-cck2r-stem-cells-in",
  "topic": "ai",
  "section": "AI",
  "published": "2026-08-31T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.08.28.747959v1?rss=1"
  },
  "original_language": "en",
  "account": "Antral CCK2R+ stem cells are influenced by gastrin, but the interaction between endocrine and neural cues during persistent injury is not fully understood. The study reveals that inducing hypogastrinemia leads to a shift from asymmetric renewal to symmetric expansion of these stem cells. Upon carcinogenic stress, these cells develop a cycling, injury-responsive progenitor state, identified through single-cell RNA profiling. The acute loss of gastrin triggers a CCK2R+ nodose DMV vagal reflex, which elevates acetylcholine release, NGF production, cholinergic innervation, and Chrm3 expression. This, in turn, activates ERK and YAP signaling in the CCK2R+ stem cells. Vagotomy, Trk inhibition, or Chrm3 deletion all suppress stem cell expansion. In models of H. pylori infection and MNU administration, hypogastrinemia exacerbates inflammation, dysplasia, and CCK2R+ clone expansion, while gastrin mitigates these effects. Human single-cell RNA sequencing and spatial profiling corroborate the findings of G cell depletion and progenitor state enrichment. The researchers propose that this endocrine neural epithelial axis, involving gastrin loss and vagal M3R signaling, could be targeted for early intervention in antral preneoplasia.",
  "summary": "Antral CCK2R+ stem cells are regulated by gastrin, but how endocrine and neural cues integrate under chronic injury remains unclear. Here we show that inducible hypogastrinemia shifts from asymmetric renewal to symmetric expansion of CCK2R+ stem cells. With carcinogenic stress, these cells acquire a cycling, injury responsive progenitor state revealed by single-cell RNA profiling. Acute gastrin…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}