{
  "id": 4683613,
  "title": "Integrin α11 is enriched in quiescence and promotes cell-cycle re-entry through destabilisation of the CDK inhibitor p27",
  "url": "https://urgent.news/2026/08/31/integrin-11-is-enriched-in-quiescence-and-promotes-cell-cycle-re",
  "topic": "science",
  "section": "Science",
  "published": "2026-08-31T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.08.29.748043v1?rss=1"
  },
  "original_language": "en",
  "account": "Integrin α11 (ITGA11) is a protein that is enriched in quiescent cells, which are cells that are not actively dividing. ITGA11 is found in multiple models of reversible quiescence in various cell types, but it is not necessary for the proliferation of cells that are actively cycling or in senescent cells. When ITGA11 is depleted from cells, it causes a defect in the return to proliferation from quiescence. This defect can be overcome by either depleting the protein p27 or by activating the YAP signaling pathway. The depletion of p27 or the activation of YAP signaling allows for the restoration of the cell-cycle re-entry that was impaired by ITGA11 depletion. These findings suggest that ITGA11 plays a crucial role in the transition from quiescence to proliferation by coupling the sensing of the extracellular matrix to the regulation of the Skp2-p27 axis through YAP-dependent mechanisms.",
  "summary": "Proteins that distinguish quiescent cells from other non-proliferative states and actively regulate their return to proliferation remain poorly understood. Here, we combined quantitative proteomics with functional image-based screening to identify regulators of the quiescence-to-proliferation transition. Amongst the functional quiescence signature proteins we identified, we focussed on integrin…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}