{
  "id": 3769410,
  "title": "CysLENS: Interpretable signatures of cysteine ligandability from enantiomeric chemoproteomics and protein language models",
  "url": "https://urgent.news/2026/08/27/cyslens-interpretable-signatures-of-cysteine-ligandability-from",
  "topic": "science",
  "section": "Science",
  "published": "2026-08-27T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.08.26.747357v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "Large chemoproteomic screens using covalent fragments map compound-cysteine engagements across the proteome, however, identifying robust, recognition-driven interactions remains a challenge due to experimental variability and electrophile reactivity. Here, we present CysLENS (Cysteine Ligandability Evaluation through Neighborhood and Chemical Similarity), an integrative framework that prioritizes…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}