{
  "id": 3761706,
  "title": "Soluble guanylyl cyclase subunits act as Hsp90 co-chaperones to ensure the expression and functional maturation of hemeproteins in mammalian cells",
  "url": "https://urgent.news/2026/08/27/soluble-guanylyl-cyclase-subunits-act-as-hsp90-co-chaperones-to",
  "topic": "science",
  "section": "Science",
  "published": "2026-08-27T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.08.26.747375v1?rss=1"
  },
  "original_language": "en",
  "account": "Soluble guanylyl cyclase (sGC) subunits play a crucial role in aiding the expression and proper development of hemeproteins in mammalian cells. These subunits act as co-chaperones alongside Hsp90, ensuring that newly generated apo-hemeproteins are stabilized and delivereed heme for their transformation into functional forms. In the study, researchers examined four different apo-hemeproteins including Hemoglobin beta, Myoglobin, Indoleamine 2,3-dioxygenase 1, and Tryptophan 2,3-dioxygenase in both sGC-expressing and sGC-deficient cell lines. The findings revealed that co-expression of either sGC subunit was vital for three out of the four apo-hemeproteins to accumulate and acquire heme in the sGC-deficient cell lines. This process did not involve heme binding, heterodimer formation, or cGMP production by the sGC subunits, but rather relied on their ability to recruit Hsp90 and GAPDH to the apo-hemeproteins via their own Hsp90 binding. This discovery sheds new light on the functions of sGC and Hsp90 in biological processes.",
  "summary": "The cofactor Fe-protoporphyrin IX cofactor (heme) performs many functions in biology. Animal cells must stabilize their newly generated heme-free (apo)-hemeproteins and deliver mitochondrial heme to them so they can mature to functional form. Glyceraldehyde 3-phosphate dehydrogenase (GAPDH) typically accomplishes the heme deliveries, and for many apo-hemeproteins, heat shock protein 90 (Hsp90)…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}