{
  "id": 3729693,
  "title": "A whole-animal phenotypic drug screen identifies suppressors of atherogenic lipoproteins",
  "url": "https://urgent.news/2026/08/27/a-whole-animal-phenotypic-drug-screen-identifies-suppressors-of",
  "topic": "health",
  "section": "Health & Medicine",
  "published": "2026-08-27T00:00:00.000Z",
  "source": {
    "name": "eLife",
    "slug": "elife",
    "url": "https://elifesciences.org/articles/105314"
  },
  "original_language": "en",
  "account": "A comprehensive study screened nearly 3000 compounds in zebrafish, yielding 49 compounds that effectively lower Apolipoprotein B (ApoB)-containing lipoproteins (B-lps). After rigorous testing, seven compounds were chosen for further phenotypic examination. Among these, enoxolone, derived from licorice root, demonstrated a significant reduction in B-lp levels, but only in zebrafish with fully functional Hepatocyte Nuclear Factor 4α (HNF4α) genes. Similarly, inhibitors of HNF4α also lowered B-lp levels. These findings highlight the effectiveness of a whole-animal zebrafish phenotypic screen in swiftly determining the mechanism of action for B-lp lowering compounds. The results strongly support the LipoGlo screening platform as a valuable tool for discovering small-molecule modulators of B-lps, which are crucial players in cardiovascular disease, a leading cause of global mortality.",
  "summary": "Lipoproteins are essential for lipid transport in all bilaterians. A single Apolipoprotein B (ApoB) molecule is the inseparable structural scaffold of each ApoB-containing lipoprotein (B-lps), which are responsible for transporting lipids to peripheral tissues. The cellular mechanisms that regulate ApoB and B-lp production, secretion, transport, and degradation remain to be fully defined. In…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}