{
  "id": 3708347,
  "title": "More accurate risk assessment developed for Alzheimer's disease among nonwhite patients",
  "url": "https://urgent.news/2026/08/27/more-accurate-risk-assessment-developed-for-alzheimers-disease-among",
  "topic": "health",
  "section": "Health & Medicine",
  "published": "2026-08-27T09:00:01.000Z",
  "source": {
    "name": "Medical Xpress",
    "slug": "medical-xpress",
    "url": "https://medicalxpress.com/news/2026-08-accurate-alzheimer-disease-nonwhite-patients.html"
  },
  "original_language": "en",
  "account": null,
  "summary": "A new multi-ancestry polygenic risk score (PRS) for Alzheimer's disease (AD) has been developed and validated, offering improved risk prediction for genetically diverse populations. The study, published in Nature Genetics, utilized summary information from genetic markers across the genome derived from over 63,000 AD cases and 484,000 age-matched controls. The multi-ancestry PRS was tested in independent ancestrally diverse samples and validated in another group of mixed ancestry, including African American, Hispanic, and East Asian populations. Compared to previously developed PRSs based on European ancestry, the new multi-ancestry PRS demonstrated better predictive accuracy for AD in all populations examined, particularly for African American, Hispanic, and East Asian individuals. This development addresses a critical challenge in the application of PRS, as previous models have been underrepresented in genetic association studies involving diverse ancestries.",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 4,
    "also_reported_by": [
      {
        "outlet": "bioRxiv",
        "title": "Chronic trazodone treatment consolidates sleep, improves memory, and reduces amyloid pathology in a mouse model of Alzheimer's disease",
        "url": "https://urgent.news/2026/08/25/chronic-trazodone-treatment-consolidates-sleep-improves-memory-and",
        "published": "2026-08-25T00:00:00.000Z"
      },
      {
        "outlet": "Medical Xpress",
        "title": "Deep sleep brain waves offer protection against Alzheimer's disease, new research shows",
        "url": "https://urgent.news/2026/08/25/deep-sleep-brain-waves-offer-protection-against-alzheimers-disease",
        "published": "2026-08-25T19:00:06.000Z"
      },
      {
        "outlet": "Phys.org",
        "title": "Nanoparticles induce neuroregeneration in Alzheimer's disease models",
        "url": "https://urgent.news/2026/08/26/nanoparticles-induce-neuroregeneration-in-alzheimers-disease-models",
        "published": "2026-08-26T15:00:16.000Z"
      }
    ]
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}