{
  "id": 370353,
  "title": "Protein 'switch' determines whether liposarcoma cells will become aggressive",
  "url": "https://urgent.news/2026/08/09/protein-switch-determines-whether-liposarcoma-cells-will-become",
  "topic": "science",
  "section": "Science",
  "published": "2026-08-09T11:40:04.000Z",
  "source": {
    "name": "Medical Xpress",
    "slug": "medical-xpress",
    "url": "https://medicalxpress.com/news/2026-08-protein-liposarcoma-cells-aggressive.html"
  },
  "original_language": "en",
  "account": "A study led by Dr. Blake Wilde of Roswell Park Comprehensive Cancer Center has uncovered how certain proteins regulate the aggressiveness of liposarcoma cells. Liposarcoma, a type of cancer that originates in fat tissue, has two primary forms: well-differentiated (WD) and dedifferentiated (DD), with the latter being faster-growing and more likely to spread. Dr. Wilde and his team discovered that a protein called PPAR-gamma acts as a \"switch\" that determines whether stem-like cells within the tumor will mature into the less aggressive, fat-like state associated with WD liposarcoma or remain in the rapidly growing, more aggressive state of DD liposarcoma. By targeting these stem-like cells and the biological pathways they control, researchers believe it may be possible to prevent manageable tumors from becoming more dangerous and recurring after treatment.",
  "summary": "New research from an expert in cancer biology explains what triggers liposarcoma cells to become more or less aggressive and identifies potential targets that could keep aggressive tumors in check. A study led by Blake Wilde, Ph.D., of Roswell Park Comprehensive Cancer Center highlights how this discovery may pave the way for new treatment options for this cancer.",
  "key_points": [
    "Protein PPAR-gamma regulates liposarcoma aggressiveness",
    "Switch determines stem-like cells' fate in tumor",
    "Targeting PPAR-gamma could prevent tumor recurrence"
  ],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}