{
  "id": 3652484,
  "title": "Proteomic Profiling of Enriched Nuclei Provides a Nuclear Proteome Resource and Protein Interaction Landscape for Trypanosoma cruzi",
  "url": "https://urgent.news/2026/08/26/proteomic-profiling-of-enriched-nuclei-provides-a-nuclear-proteome",
  "topic": "science",
  "section": "Science",
  "published": "2026-08-26T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.08.25.746806v1?rss=1"
  },
  "original_language": "en",
  "account": "Research has identified a complete nuclear proteome and interaction landscape for the protozoan parasite Trypanosoma cruzi. Proteomic profiling of intact nuclei, through high-resolution mass spectrometry, revealed 1,734 proteins, 316 of which contained post-translational modifications. Computational analysis, using the STRINGDB database, organized the proteins into functional clusters, including a neighborhood of histone-associated interactions. Crosslinking mass spectrometry further detected 26 residue-resolved protein-protein crosslinks, involving 36 proteins, and identified post-translational modifications at or near the linked residues. This comprehensive resource paves the way for comparative nuclear proteomics studies, multi-omics integration, and the prioritization of potential targets for functional investigations.",
  "summary": "The processes such as DNA replication, transcription, and repair are often modulated by specific nuclear proteins, protein-protein interactions (PPIs), and post-translational modifications (PTMs). In Trypanosoma cruzi, however, the nuclear proteome and interactome have not been systematically mapped, limiting the interpretation of nuclear regulatory processes. Here, we report a nuclear proteome…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}