{
  "id": 34693,
  "title": "Potential mediating role of triglycerides in the nonlinear association between body roundness index and MASLD in nondiabetic adults",
  "url": "https://urgent.news/2026/08/02/potential-mediating-role-of-triglycerides-in-the-nonlinear",
  "topic": "science",
  "section": "Science",
  "published": "2026-08-02T00:00:00.000Z",
  "source": {
    "name": "Scientific Reports",
    "slug": "scientific-reports",
    "url": "https://www.nature.com/articles/s41598-026-65063-w"
  },
  "original_language": "en",
  "account": "A Chinese study found that a measure of visceral adiposity, known as the body roundness index (BRI), has a strong and nonlinear relationship with metabolic dysfunction-associated steatotic liver disease (MASLD) in non-diabetic adults. After accounting for various factors, higher BRI was independently linked to increased MASLD risk, with women, individuals aged 40 or older, those with a body mass index over 25 kg/m², and non-hypertensive individuals experiencing stronger associations. Generalized additive models showed an inverted-U-shaped association between BRI and MASLD, with a saturation point at BRI equal to 4.80. Further analysis suggested that triglyceride levels may partially mediate the connection between BRI and MASLD, accounting for 12.08% of the total statistical effect. The findings indicate that elevated BRI is strongly and nonlinearly associated with MASLD risk, even in traditionally low-risk subgroups, and that serum triglycerides might play a role in the pathway from visceral fat accumulation to hepatic steatosis, warranting further prospective research.",
  "summary": "Scientific Reports, Published online: 02 August 2026; doi:10.1038/s41598-026-65063-w Potential mediating role of triglycerides in the nonlinear association between body roundness index and MASLD in nondiabetic adults",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}