{
  "id": 3328812,
  "title": "15-deoxy-Δ12,14-prostaglandin J2 limits Salmonella infection through regulation of host TLR4 signaling and inflammasome activation",
  "url": "https://urgent.news/2026/08/25/15-deoxy-12-14-prostaglandin-j2-limits-salmonella-infection-through",
  "topic": "science",
  "section": "Science",
  "published": "2026-08-25T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.08.24.746850v1?rss=1"
  },
  "original_language": "en",
  "account": "Enteric infections caused by Salmonella enterica pose a significant global health issue, exacerbated by the rise of antimicrobial resistance. Researchers have long studied the interactions between the pathogen and the human host, but recent discoveries persist. Previously, scientists found that 15-deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2) reduces Salmonella colonization in macrophages, yet the mechanisms behind this protective effect remained unclear. In this study, the researchers reveal that 15d-PGJ2 limits Salmonella infection by suppressing TLR4 signaling and inflammasome activation. By treating macrophages with 15d-PGJ2, the study shows a decrease in TLR4 expression, NF-κB activation, iNOS, COX-2, nitric oxide production, IL-1β release, and inflammasome-related targets like NLRP3 and caspase-1 activity. While the treatment partially reversed macrophage polarization, it significantly reduced macrophage colonization by Salmonella and IL-1β release. Mice infected with the pathogen also exhibited reduced bacterial burdens when treated with 15d-PGJ2, demonstrating the compound's effectiveness in inhibiting Salmonella infection through selective modulation of TLR4 signaling and inflammasome activation.",
  "summary": "Enteric infections caused by Salmonella enterica remain a major global health concern and are increasingly associated with antimicrobial resistance. Therefore, new strategies to combat this important pathogen are needed. The interactions between S. enterica and the human host have been the subject of intense investigation over the last several decades, yet new findings continue to emerge. We…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}