{
  "id": 30963,
  "title": "Risk factors for incident chronic kidney disease following unilateral nephrectomy: a systematic review and meta-analysis",
  "url": "https://urgent.news/2026/08/02/risk-factors-for-incident-chronic-kidney-disease-following-unilateral",
  "topic": "health",
  "section": "Health & Medicine",
  "published": "2026-08-02T00:00:00.000Z",
  "source": {
    "name": "Scientific Reports",
    "slug": "scientific-reports",
    "url": "https://www.nature.com/articles/s41598-026-64417-8"
  },
  "original_language": "en",
  "account": "A systematic review and meta-analysis of 26 adult cohort studies involving 13,321 patients has identified risk factors for postoperative chronic kidney disease (CKD) after unilateral nephrectomy. The research, supported by grants from the Natural Science Foundation of Shandong Province, reveals several key associations. Advanced age, male sex, diabetes mellitus, lower preoperative estimated glomerular filtration rate (eGFR), higher preoperative serum creatinine, and radical nephrectomy were significantly linked to an increased risk of postoperative CKD. Conversely, higher baseline eGFR reduced CKD risk. Each additional year of age was associated with a 5% higher likelihood of CKD (adjusted OR = 1.05, 95% CI: 1.03--1.08). Compared to partial nephrectomy, radical nephrectomy significantly raised CKD risk (adjusted OR = 3.73, 95% CI: 2.27--6.13). Subgroup, leave-one-out sensitivity, and publication-bias analyses confirmed the robustness of these findings, though publication bias was noted for certain variables. The study concludes that advanced age, diabetes, lower preoperative kidney function, and radical nephrectomy are associated with a higher CKD risk after unilateral nephrectomy. Preoperative risk assessment, nephron-sparing surgery when oncologically appropriate, and risk-adapted follow-up are recommended to mitigate the postoperative CKD burden.",
  "summary": "Scientific Reports, Published online: 02 August 2026; doi:10.1038/s41598-026-64417-8 Risk factors for incident chronic kidney disease following unilateral nephrectomy: a systematic review and meta-analysis",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}