{
  "id": 3043864,
  "title": "Gestational exposure of bisphenol-A limits decidual ECM organization via S100a10-Annexin A2 axis in murine placenta",
  "url": "https://urgent.news/2026/08/24/gestational-exposure-of-bisphenol-a-limits-decidual-ecm-organization",
  "topic": "science",
  "section": "Science",
  "published": "2026-08-24T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.08.22.746430v1?rss=1"
  },
  "original_language": "en",
  "account": "A recent study investigates the effects of bisphenol-A (BPA) exposure during pregnancy on placental tissue remodeling. BPA, an endocrine-disrupting chemical, can negatively impact the developing feto-placental unit. The researchers used a mouse model to examine the impact of BPA on the placenta, which plays a crucial role in maintaining fetal health during pregnancy.\n\nThe findings indicate that BPA exposure leads to altered phenotypic changes in the feto-placental interface, along with a perturbed placental proteome. Further analysis reveals an S100a10-Annexin A2 axis that is responsible for upregulation of tissue plasminogen activator (tPA). This upregulation drives altered ECM degradation in the placental decidua, resulting in functional dysregulation of the feto-placental axis.\n\nThe impaired ECM remodeling due to BPA exposure leads to a reduced size of both the fetus and placenta, which may ultimately result in adverse pregnancy outcomes related to toxicity. This study provides valuable insights into a novel mechanism that contributes to BPA-induced alterations in ECM remodeling within the placental decidua.",
  "summary": "Environmental exposure to endocrine disrupting chemicals, like bisphenol-A (BPA), can impart detrimental effects on developing feto-placental unit, during pregnancy. Placenta remains a central player maintaining this feto-placental homeostasis for sustenance of a healthy pregnancy. Thus, the bisphenol-A mediated endocrine disruption affects the healthy functioning of placenta by altering key…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}