{
  "id": 3028721,
  "title": "SOX2 terminates trophectoderm competence in inner cell mass by closing trophectoderm enhancers",
  "url": "https://urgent.news/2026/08/24/sox2-terminates-trophectoderm-competence-in-inner-cell-mass-by",
  "topic": "science",
  "section": "Science",
  "published": "2026-08-24T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.08.22.746397v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "During embryonic development, cellular competence to respond to differentiation signals changes dynamically. Although the mechanisms underlying competence acquisition have been extensively studied, those underlying competence loss remain unclear. In preimplantation mouse embryos, Hippo signaling shifts from regulating trophectoderm (TE) fate specification to promoting epiblast maturation. During…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}